Dr Ioannis Michalopoulos and Dr Apostolos Malatras are Guest Editors of Special Issue “Differential Gene Expression and Coexpression (3rd Edition)” of Biology (Impact Factor 3.5, JCR category rank: Q1: Biology). Deadline for manuscript submissions: 31 December 2026.

The most common approach in transcriptomics (RNA-seq and microarrays) is differential gene expression analysis. Genes identified as differentially expressed may be responsible for phenotype differences between various biological conditions. An alternative approach is gene co-expression analysis, which detects groups of genes with similar expression patterns across unrelated sets of transcriptomic data from the same organism. Coexpressed genes tend to be involved in similar biological processes. This Special Issue will include reviews and research articles on the topic of differential gene expression and coexpression. The reviews will provide an overview of the methods available for transcriptomic analysis, while the research articles will provide an in-depth description of each state-of-the-art tool. Please send me an abstract prior to submission to ensure that your work falls within the scope of this Special Issue.